Simpson said police are searching for the shooter, who fled the scene and who might have been accompanied by other people.
The shooter may be affiliated with a gang, Simpson said, but it's not known if the shooting was gang-related or "a personal beef."
He said the police department's gang task force was investigating. Agents from the FBI and the Bureau of Alcohol, Tobacco, Firearms and Explosives also arrived to assist in the investigation.
The shooting happened about a quarter past noon (3:15 p.m. ET) outside the alternative high school, which is designed to help students who don't thrive in a traditional school setting, Simpson said.
Simpson said the campus is safe now. "This is not an active shooter situation," he said.
Nearby Jefferson High School and Portland Community College were put on lockdown as police sought the shooter, authorities said.
Another school shooting occurred June 10 at Reynolds High School in Troutdale, about 12 miles east of Portland. One person was killed. VIDEO